10/28/43 Mother's letter to EC: "I'm enclosing a record of
[
3289]'s illness. When we were in Virginia Beach you asked
us to send it.
"We are anxiously awaiting the report of the check reading
and know we will find something helpful in it.
"Thank you again for your helpful cooperation..."
"Patient, age 7, supposedly has cystitis and pyelitis. In
about February 1940 she had a gastrointestinal disturbance
which consisted of repeated attacks of vomiting and diarrhea.
These attacks continued intermittently every two or three
weeks for about three months.
"X-ray pictures were negative. At about this same time she
started wetting herself during the day. A doctor's
examination of her urine showed some pus cells. No
medication was given. In August 1940 she had an acute attack
of pyelitis; urine culture showed colon bacteria, temperature
105 degrees, treated with sulfanilamide. After about three
weeks she was cured. Had no further symptoms either
gastrointestinal or urinary. In January 1941 she complained
of burning sensation on urination and headaches. Examination
showed pus in urine and sulfanilamide was again given; urine
cleared. In March 1941 she again repeated symptoms: pus,
frequency of urination and was treated with mandelic acid and
continued taking mandelic acid for a period of 30 days.
After which period, she showed great amounts of blood in
urine. The medication was immediately discontinued - result
- no blood. Patient was then taken to hospital. Complete
x-ray pictures of the urinary tract were made (dye injected
into vein), showed no malformation or anomalies [?]. Urine
cultures were negative.
"The wetting continued consistently with headaches: After
about a month, urine again showed pus and she was put on a
sulfa preparation which did not clear the urine.
"In July 1941 she was put on a complete alkaline diet for
about thirty days; no improvement in patient, frequency and
urgency and burning increased, no relief from headaches or
pus in the urine.
"About August 1, 1941, she was taken to Mayo's Clinic. Urine
culture showed colon bacillus and streptococcus fecatis [?].
She was given calcium mandelate and in four days urine
culture was negative. All symptoms gone with exception of
frequency. In two weeks medication was discontinued and four
or five days thereafter urine again showed pus, headaches
returned and cultures showed strept fecalis [?] whereupon
mandelic acid was again given. In the middle of September
1941, a cystoscopic examination revealed trabeculation of the
bladder and apparent tightening of sphincter muscle. Tests
taken at that time also revealed residual urine and operation
to relax muscle was suggested. After sphincterectomy
operation she was apparently 100% okay; all symptoms having
disappeared with exception of occasional blood cell and
occasional pus cell. Small amounts of sulfathiazole [?] was
given immediately after operation and continued until early
part of December when all symptoms - headaches, wetting, etc.
returned. Urine culture showed pus, strep fecatis [?].
Another cystoscopic examination revealed slight submucosal
pustule [?] which was coderized [?]. Medication was changed
to calcium mandelate. After two week period urine was again
sterile, frequency continued. After discontinuing medicine
for four or five days she again had all the symptoms back -
headaches, pus strep fecatis [?]. Calcium mandelate was
again given and continued up to the present time; patient
remaining sterile ever since, the only remaining symptoms
being continuous urgency and frequency. Tests were made
intermittently subsequent to January 1942 by discontinuing
medication two or three days - immediately following which
all symptoms would return - pus, burning, headaches, strep
fecatis [?] and colon bacillus.
"August 1942 cystoscopic examination showed no change in
bladder, slight amount of pus coming from left kidney, no
change in trabeculation. X-ray of urinary tract again
revealed nothing. At this same time examination and tests of
colon and bowel were made which were normal.
"Urine must remain acid at all times or infection returns
immediately."
10/28/43 See
3289-2.



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